ATLASBLOOD, BONE MARROW, SPLEEN
      AND CNS PARASITES
      ZOOMASTIGOPHOREA Order: Kinetoplastida

      TRYPANOSOMA BRUCEI RHODESIENSE / T.B. GAMBIENSE

      Adapted and redrawn from NCDC

      tryp1-ic

      Trypanosoma brucei gambiense and rhodesiense: life cycle.


      Geographic distribution of Human African Trypanosomiasis (Sleeping Sickness)

      tryp2-ic

      Sleeping sickness occurs in Africa between the 15° North and the 20° South.
      The T.b.rhodesiense form is found in East and Central-East Africa whereas the
      T.b.gambiense infection occurs in Central and West Africa.

      (Adapted and redrawn form: a) Epidemiology and Control of African Trypanosomiasis,
      Report of a WHO Expert Committee, Technical Report series, No 739, 1986;
      b)Trypanosomiasis Weekly Epidemiological Report, 1990, 50, 388-391.)




      Courtesy of Bayer, from Bayer Manual of Pest Control By Emeritus Professor Wallace Peters By Emeritus Professor Wallace Peters

       tryp2a-ic                  tryp2b-ic                   tryp2c-ic

      tryp2a: T.b.gambiense and rhodesiense: about 20.000 cases
      occur annually in the endemic areas.
      The African trypanosomiasis is transmitted
      by several species of tse-tse flies (Glossina spp.).

      tryp2b: Larva and pupae of Glossina morsitans 

      tryp2c: Adult Glossina tachinoides in West Africa

      tryp2a-ic Glossina spp.:  
      Courtesy of Bayer, from Bayer Manual of Pest Control

      tryp2b-ic  tryp2c-ic Glossina spp.: 
      Courtesy of Emeritus Professor Wallace Peters: 
       Director, Tropical Parasitic Disease Unit, 
      Nortwick Park Insitute for Medical Research



      tryp3-ic

      T. b. gambiense and rhodesiense: two forms of trypomastigote
      can be seen in peripheral blood: one is long slender, 30 µm in lenght,
      and is capable of multiplying in the host, the other is stumpy, not dividing,
      18 µm in lenght.


      tryp4-ic

      Trypanosoma brucei gambiense and rhodesiense: trypanosomes appear
      in the peripheral blood 5 to 21 days after the infecting bite.


      tryp5-ic

      Trypanosoma brucei gambiense and rhodesiense: the terminal stage of
      the infection ("sleeping sickness") is the result of a chronic
      meningoencephalomyelitis. (H&E stain).


      tryp6-ic

      Trypanosoma brucei gambiense and rhodesiense: the typical pathological lesion
      of trypanosomiasis is a perivascular round-cell infiltration (perivascular cuffing)
      due to glial cells, lymphocytes and plasmocytes (Mott cells).
      (H&E stain).


      CENTRAL....BLOOD....